Syntheses of Novel Derivatives of NMDARs Allosteric Modulators
Lead optimization is one of the most crucial links in the process of drug design. Otava Research institute presents the full complex of services to improve the chemical and physical parameters of lead molecule according to your specific target.
N-methyl-D-aspartate receptors (NMDARs) are ligand-gated ion channels wich is activated by L-glutamate (the brain’s primary excitatory neurotransmitter). They have many critical roles in CNS function and in various neurological and psychiatric disorders.
We offer the chemical optimization service - syntheses of NMDARs targeted-specific sets of novel sulfonamides, quinazoline-4-ones, pyrazolines, iminothiazolidinones, N-arylbenzamides, coumarin-3-carboxylic acids, benzenesulfonamides, thiazoles and tetrahydroisoquinolines for your biological projects. These novel compounds will be selected from a sets of 1,000 - 2,000+ unique virtual derivatives for each chemical class using our company’s proprietary molecular modeling platform.
These target-specific sets of novel derivatives will be synthesized exclusively upon your request.
Novel derivatives of NAMs and PAMs provide a perfect basis for drug discovery projects related with pain, stroke, epilepsy, schizophrenia, post-traumatic stress disorder, depression and various neurodegenerative diseases such as Alzheimer’s and Parkinson’s.
To get the qualified quotation for the lead optimization please fill the contact form or contact us directly